Reply to “Tolerogenic insulin peptide therapy precipitates type 1 diabetes”
نویسندگان
چکیده
In this issue of JEM, Bergman et al. (https://doi.org/10.1084/jem.20160471) challenge the data published in our previous JEM paper on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Here, we provide a response to these data and suggest that appropriate subimmunogenic conditions are required to induce Foxp3+ regulatory T cell conversion.
منابع مشابه
Tolerogenic insulin peptide therapy precipitates type 1 diabetes
Daniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its inciden...
متن کاملCD40 Knocked Down Tolerogenic Dendritic Cells Decrease Diabetic Injury
Background: Type-1 diabetes (T1D) is an autoimmune disease in which T lymphocytes destroy insulin-producing β-cells. Control of self-reactive T lymphocytes and recovery of diabetic injury is the end point of T1D. Objective: To investigate generation of tolerogenic dendritic cells (tolDCs) as an innovative method of diabetes therapy. Methods: Lentivirus vector production was achieved by GIPZ mou...
متن کاملResponse to comment. Is incretin-based therapy ready for the care of hospitalized patients with type 2 diabetes?
We thank Drs. Deane and Horowitz (1) for bringing this work to our attention. Their results provide further support for our contention that glucagon-like peptide 1 (GLP-1) therapy represents a safe and effective intervention to improve glycemic control in critically ill, hospitalized patients both with and without preexisting type 2 diabetes. In agreement with us (2), they recognize that “insul...
متن کاملImmunotherapy with Tolerogenic Dendritic Cells Alone or in Combination with Rapamycin Does Not Reverse Diabetes in NOD Mice
Type 1 diabetes is a metabolic disease caused by autoimmunity towards β -cells. Different strategies have been developed to restore β -cell function and to reestablish immune tolerance to prevent and cure the disease. Currently, there is no effective treatment strategy to restore endogenous insulin secretion in patients with type 1 diabetes. This study aims to restore insulin secretion in diabe...
متن کاملCharacteristics and Prevalence of Latent Autoimmune Diabetes in Adults (LADA) in Torbat-e Heydarieh, Iran
Background and Aims: The prevalence of latent autoimmune diabetes in adults (LADA) among diabetic patients is less recognized and underdiagnosed. The aim of this study was to determine the prevalence of LADA in type 2 diabetic patients and to compare the characteristics of these two groups in Torbat-e Heydarieh, Iran. Materials and Methods: Totally, 198 male and 277 female patients diagnosed ...
متن کامل